The administration of adenine nucleotides or adenosine and inorganic phosphate to a human host results in the generation of elevated liver, other organs and red blood cell adenosine 5'-triphosphate (ATP) pools as well as increased levels of ATP and adenosine in the extracellular blood plasma compartment of the blood. The present invention deals with the utilization of the elevated intracellular ATP levels and the elevated extracellular levels of ATP and adenosine for the treatment of a broad spectrum of clinical targets in HIV disease/AIDS and the achievement of decisive therapeutic gains.