According to an aspect of the invention, implantable or insertable medical
devices are provided which contain the following: (a) one or more porous
regions comprising pores and (b) one or more therapeutic agents which are
(i) contained within the porous region, (ii) disposed beneath the porous
region, or (iii) both. Moreover, the porous regions are capable of
undergoing a change in configuration, such that the pores undergo a
change in configuration, upon subjecting the porous regions to activating
stimuli.