A computer-implemented method for determining a joint space width includes providing image data for a skeleton, thresholding the image data, and performing a connected component analysis on thresholded image data. The method further includes extracting contours of the thresholded image data according to the connected component analysis, performing a skeletonization of the thresholded image data using a first fast marching analysis of the thresholded image data, locating at least one finger joint of skeletonized image data, extracting bone boundaries using a second fast marching analysis of gradient information of the image data inside a region of interest, which includes a finger joint of the at least one finger joint, determining the joint space width given extracted bone boundaries, and outputting the joint space width.