This document discusses, among other things, a system and method for providing a stimulus signal of a closed loop neuromodulator configured to optimize sleep therapy for a patient. A stimulus select signal can be received at a plurality of stimulus type generators from a stimulus sequencer of the closed loop neuromodulator, and a stimulus signal can be provided using one of the plurality of stimulus type generators in response to the stimulus select signal. An amplified stimulus signal can be provided to a stimulus escalator of the closed loop neural modulator to optimize sleep therapy for the patient.