The present invention provides compositions and methods for enhancing the
neuroprotective effect of umbilical cord blood cells. More particularly,
the present invention provides methods of treating neurodegenerative
disorders by administering umbilical cord blood cells and a substance
capable of permeabilizing the blood brain barrier. In one embodiment, the
blood brain barrier permeabilizer is mannitol. In another embodiment, the
blood brain barrier permeabilizer is Cereport.