A method for increasing the bioavailability of cysteine within an animal
by reducing extracellular cysteine disulfide molecules to produce
extracellular cysteine molecules. A membrane permeable thiol molecule
that forms a membrane permeable disulfide molecule after becoming
oxidized participates in thiol-disulfide exchange reactions on both sides
of the cellular membrane, crossing the membrane randomly via simple
diffusion. The membrane permeable disulfide, within or upon entering the
highly reductive environment of a cell, becomes reduced to form a
membrane permeable thiol molecule. the membrane permeable thiol can then
diffuse to the exterior of the cell, where it is available to reduce
another cystine molecule. This process can continue cycling, producing
net cumulative increase in the concentration of extracellular cysteine.
This is beneficial for providing cysteine as a nutrient to cells that
require cysteine for nourishment.