An organic light emitting diode drive circuit includes an organic light emitting diode which emits light with a current, a first transistor, a second transistor and a stress compensation circuit. The first transistor supplies a data voltage to a first node in response to a scan pulse. The second transistor controls a current flowing in the organic light emitting diode by the data voltage on the first node. The stress compensation circuit discharges the first node in response to a reset pulse. The organic light emitting diode driving circuit is adaptive to compensate characteristic changes of the organic light emitting diode drive circuit.