Compounds comprising: ##STR00001## or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y is a carboxylic acid functional group, sulfonic acid functional group, or phosphonic acid functional group; or an amide or ester thereof comprising from 0 to 12 carbon atoms; or Y is a hydroxymethyl, or tetrazolyl functional group; A is --(CH.sub.2).sub.6--, cis --CH.sub.2CH.dbd.CH--(CH.sub.2).sub.3--, or --CH.sub.2C.ident.C--(CH.sub.2).sub.3--, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is --(CH.sub.2).sub.m--Ar--(CH.sub.2).sub.o wherein Ar is substituted or unsubstituted phenyl or monocyclic heteroaryl, the sum of m and o is from 1 to 4, and wherein one CH.sub.2 may be replaced by with S or O; R, D, and n are as described. Methods, compositions, and medicaments related thereto are also disclosed.