The invention provides novel compounds useful for the treatment of
neurodegenerative disorders including Alzheimer's disease and dementia.
The compounds have a substituents chosen from -L-C(.dbd.O)OH,
-L-CH.dbd.CHC(.dbd.O)OH, -L-C(.dbd.O)NH.sub.2, -L-C(.dbd.O)NH(C.sub.1-3
alkyl), -L-C(.dbd.O)N(C.sub.1-3 alkyl).sub.2,
-L-S(.dbd.O).sub.2(C.sub.1-3alkyl), -L-S(.dbd.O).sub.2NH.sub.2,
-L-S(.dbd.O).sub.2N(C.sub.1-3 alkyl).sub.2,
-L-S(.dbd.O).sub.2NH(C.sub.1-3 alkyl), -L-C(.dbd.O)NHOH,
-L-C(.dbd.O)CH.sub.2NH.sub.2, -L-C(.dbd.O)CH.sub.2OH,
-L-C(.dbd.O)CH.sub.2SH, -L-C(.dbd.O)NHCN, -L-NHC(.dbd.O)OR.sub.o,
-L-C(.dbd.O)NHR.sub.o, -L-NH(C.dbd.O)NHR.sub.o,
-L-C(.dbd.O)N(R.sub.o).sub.2, -L-NH(C.dbd.O)N(R.sub.o).sub.2, -L-sulfo,
-L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a
linker.
