The invention relates to the treatment of intestinal barrier function disorders involving administration of a selected colostrum comprising more than 25 weight % undenatured immunoglobulin G(IgG) based on the weight of total protein content of said colostrum to a subject. The invention further relates to compositions comprising colostrum and indigestible dietary fibers wherein the colostrum comprises more than 25 weight % undenatured immunoglobulin G based on the weight of total protein content of said colostrum.