A bioresorbable fibrin-based nerve repair conduit produced from tissue
glue is disclosed. The nerve repair conduit may be in the form of a sheet
or a tube, and may additionally comprise a serine protease, and/or Factor
XIII and/or calcium ions. The serine protease is chosen from the group
consisting of trombin, plasmin, elastases, and plasminogen activators, or
combinations thereof. The nerve repair conduit may moreover be loaded
with Schwann cells and/or Stem cells and/or growth factors, for better
nerve regeneration. Further, a method of producing the above-mentioned
nerve repair conduit is provided, comprising curing fibrinogen and serine
protease containing fluids in the form of a fibrinogen-containing tissue
glue, in a mould equipped with a central shaft creating a channel in the
nerve repair conduit when removed. Moreover, use of a fibrinogen-based
tissue glue for the preparation of a fibrin-based nerve repair conduit is
described. A method of treating nerve damage by placing a nerve repair
conduit according to the invention around at least one nerve stump and
allowing the nerve repair conduit to guide the nerve stump during
regeneration is also provided.