Port number emulation for wireless Universal Serial Bus (USB) connections is provided. Virtual USB port numbers are emulated and associated with external devices that are wirelessly connected to a host device. The associations are maintained in a data structure. When a wireless external device connects with the host device after a period of disconnection, the emulated port number associated with the wireless external device is identified. The virtual port number is provided to a software component in the host device so that the external device can resume interaction with software components in the host device across enumerations. In one example implementation, the virtual USB port numbers are provided to a plug and play manager, which handles the wireless USB devices in a manner similar to wired USB devices.