The invention concerns a device for ocular delivery of an active principle by peroperative intraocular iontophoresis or electroporation comprising a reservoir (7) for receiving a solution comprising the active principle, means for diffusing (8, 6) the active principle connected to the reservoir, means for injecting (4) the solution into the reservoir, and means (5) for exerting suction of the content of the reservoir during an injection of the solution therein by the injection means.