Systems, methods, and computer program products for reconfiguring computer instructions to accelerate a given instruction set. At run time, during the loading of a class (in the context of objected oriented programming, for example), method invocations that have arguments that meet certain conditions are replaced by faster processing methods, which are made available in a support class that replaces the originally invoked class. In one embodiment, conditions to be met by arguments include that an argument refer to a constant value, be at a specified position in an argument list, or exhibit a pre-determined pattern, form, or type (e.g., be an alpha-numeric string only, an integer in a given range, or a specific integer).