Provided is a method for treating depression with an open-channel
antagonists of the NMDA (N-methyl-D-aspartate) receptor complex. The
open-channel antagonists include memantine (a
1-amino-3,5-dimethyl-adamantane hydrochloride), felbamate, acamprosate,
and MRZ 2/579 (1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride).
The method includes oral, controlled or sustained release, intravenous,
rectal, transcutaneous or other preparations such as lipid emulsion or
crystal technology administration of the open-channel antagonist.