An indexing value may be determined, transparently with respect to a requester, based on a desired plaintext item of data and a cryptographic key. The indexing value may be used to access an entry in an indexing structure to obtain a corresponding database entry which includes a non-deterministically encrypted ciphertext item. In another embodiment, an indexing structure for a database may be accessed. Positions of items of the indexing structure may be based on corresponding plaintext items. References related to the corresponding plaintext items in the indexing structure may be encrypted and other information in the indexing structure may be unencrypted. A portion of the indexing structure may be loaded into a memory and at least one of the encrypted references related to one of the plaintext items may be decrypted. The decrypted reference may be used to access a corresponding non-deterministically encrypted data item from the database.