Disclosed is a combination perfusion and occlusion device that can have a perfusion member, an occlusive member and an elongate member. The perfusion member can be an elongate perfusion member that can have a collapsed configuration and an expanded configuration. In the collapsed configuration, the perfusion member can be disposed around the elongate member. In the expanded configuration, the perfusion member can define a perfusion lumen. The occlusive member can have a collapsed configuration and an expanded configuration. The occlusive member in the collapsed configuration can have a low profile that can facilitate insertion of the occlusive member in a body lumen. In the expanded configuration the occlusive member can be a structure that restricts the flow of fluids through a body vessel, for example a filter or another structure that restricts the flow of fluids. The occlusive member can be disposed on the elongate member, for example on a distal portion of the elongate member.

 
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> Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury

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