In one embodiment, a method for estimating the cardinality of one or more tags in a system that has the one or more tags and one or more readers. The reader issues a command requesting that the tags identify themselves. The command includes timing information defining a total number of timeslots. In response to the command, each of the one or more tags (i) selects a timeslot in which to reply to the command and (ii) issues a reply in the selected timeslot. The method includes: (a) issuing the command; (b) receiving, in one or more timeslots, replies from the one or more tags; and (c) deriving an estimate of the cardinality of the one or more tags in the system based on at least one of: (i) the number of zero slots, wherein a zero slot is a timeslot that has no tags transmitting therein, (ii) the number of singleton slots, wherein a singleton slot is a timeslot that has only one tag transmitting therein, and (iii) the number of collision slots, wherein a collision slot is a timeslot that has more than one tag transmitting therein.