A hazardous material transfer system for the transfer of waste from a containment cell through a transfer port to a storage vessel. A port door in the containment cell is movable between a open and closed positions relative to the transfer port. The port door has a closure face with a first connector set. A storage vessel sealed by a storage vessel cover is provided for receipt of waste transferred through the port. The cover has an outside face that carries a second connector set that interlocks with the first connector set on the port door. The inside face of the vessel cover has a third connector set. A fourth connector set is located on the storage vessel and mates with the third connector set to lock and seal the cover to the vessel. The connector sets are the variety that engage and disengage upon rotational motion.