The invention relates to any isolated or synthetic compound and, in
particular, to compounds having formula which can: modulate the cell
specification of neural stem cells, promote the differentiation and
subsequent survival of differentiating glial cells and neurones, and
promote the differentiation of oligodendrocyte precursor cells into
mature oligodendrocytes. In addition, the inventive compounds can reduce
the inflammatory component of diseases that affect the nervous system,
for example, by reducing activation of the microglia an/or astrocytes
and/or by reducing reactive gliosis. The invention also relates to the
methods of preparing such compounds and to the use of same in the
preparation of a pharmaceutical composition that is intended for the
prevention or treatment of diseases that affect the nervous system. More
specifically, the inventive compounds have general formula.