A method and or a device for comprehensive temperature calibration of a full width array (FWA) image sensor may minimize loss of productivity and/or image quality. Multiple temperature sensors disposed along a width of the FWA image sensor may provide temperature points used to correct for temperature shifts in output of individual pixel sensors of the FWA image sensor. Under control of a microprocessor, a real-time correction may be calculated for each pixel of the FWA image sensor. The correction may be based upon a real-time temperature profile of the FWA image sensor and temperature dependent factors of at least one calibration equation. The factors may be predetermined, or be determined at factory test, at warm-up or at a specified time.