Certain embodiments of the present invention provide a method for performing tomosynthesis including: receiving an image representative of an anatomy of a patient; allowing an interaction with the image to arrange at least one element with respect to the image to form an arrangement; and prescribing at least one parameter for obtaining a tomosynthesis image based at least in part on the arrangement. In an embodiment, the method further includes performing tomosynthesis in accordance with the at least one parameter. In an embodiment, the at least one element includes a detector representation. In an embodiment, the at least one element includes at least one thickness guide. In an embodiment, the at least one element includes at least one slice location guide. In an embodiment, the at least one parameter includes at least one of: a detector position, a detector size, a thickness size, a thickness position, a slice size, a slice position, a slice thickness, a slice separation, a field of view, a reconstruction algorithm, a hanging protocol, and an image processing routine. In an embodiment, the at least one parameter includes at least one of: an x-ray source location, an x-ray source angulation, an x-ray beam intensity, an x-ray beam gating, and a detector sensitivity.