Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.

 
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> Hemojuvelin or dragon-like 2 (DL-2) polypeptides and variants and uses thereof

> Human hemojuvelin (HJV) or dragon-like 1 (DL-1) polypeptides and variants and uses thereof

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