A vapor-permeable and waterproof sole for shoes, including a tread including a plurality of through holes, a multilayer pack, arranged superimposed on the region where the through holes are provided and including a membrane, permeable to water vapor and impermeable to liquids, and a protective layer, arranged directly below the membrane. The tread is overmolded onto the pack and further surrounds the edges, the lower perimetric portion, and the upper perimetric portion of the pack to form a perimetric seal adapted to avoid rise of liquids. The pack includes a vapor-permeable or perforated layer element, arranged directly below the protective layer, superimposed on the through holes region. The layer-like element avoids contact of the molding polymeric material with the protective layer during tread molding, and is further associated with the protective layer.