The target is to provide PDE IV inhibitors which have a highly potent
anti-asthmatic and/or COPD-prophylactic/therapeutic profile with
unexpectedly excellent safety. A compound of the formula (1):
##STR00001##
wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be
unsubstituted or optionally substituted with one or more members selected
from the group consisting of hydroxyl, halogen, cyano, nitro, lower
alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower
alkoxy-carbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower
alkylene, lower alkylsulfonyl, lower alkylsulfonyl-amino, and ureido;
R.sup.1 is a group selected from the group consisting of hydrogen,
hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower
alkoxycarbonyl; R.sup.2 is hydrogen or lower alkyl; and m is an integer
of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses
highly excellent PDE IV-specific inhibitory actions and is useful as an
anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with
high safety.