The disclosure provides a description of a tissue modulation device, for
treating at least one of obesity, metabolic syndrome, and Type 2 diabetes
in a patient. In some embodiments, the device includes a storage module
having computer-readable instructions for delivering an electrical
stimulation pattern to a splanchnic nerve of the patient. The stimulation
pattern includes at least one on-time. The on-time includes at least one
of a suprathreshold period and a subthreshold period. The splanchnic
nerve is selected from the group consisting of the greater splanchnic
nerve, the lesser splanchnic nerve, and the least splanchnic nerve. The
pattern is effective to ameliorate at least one attendant condition of
obesity, metabolic syndrome, and Type 2 diabetes in the patient. The
attendant condition includes dyslipidemia, hypertension,
hyperinsulinemia, hyperglycemia, and/or insulin resistance.