To identify a domain in HIF-1.alpha. protein, which participates in stabilization of a fused protein, DNA encoding the following polypeptide (A) or (B) is provided:(A) a polypeptide having the amino acid sequence of SEQ ID NO: 1(B) a polypeptide having an amino acid sequence comprising at least 16 amino acid residues in the amino acid sequence of SEQ ID NO: 1, and imparting stability dependent on an oxygen concentration to other protein in a cell harboring a fused protein, when the polypeptide is fused with a nuclear localization signal and the other protein to form the fused protein.

 
Web www.patentalert.com

< Diagnosis of human glycosylation disorders

> Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine

> Methods and compositions relating to gene silencing

~ 00598