In one embodiment, a method is provided for lowering PPAR-Gamma in a
mammal. The method comprises administering a composition containing an
effective amount of Irvingia gabonensis seed to a mammal to reduce
PPAR-Gamma levels in the mammal. In other embodiments, among other
things, methods are provided for reducing triglyceride levels, inhibiting
or reducing G3PDH activity, reducing body weight and increasing
adiponectin levels in a mammal by administering Irvingia gabonensis.