A received RF signal can include data information intended for transmission over a wireless communication link. The data information of the signal can be processed at a node to produce overhead bits supporting a serial transmission of the data information over a communication medium to another node. For example, the data information of the received signal and overhead bits can be combined or framed according to a serial transport protocol for transmission over the communication medium. This technique of mapping or framing the data information into a serial transport protocol is used to more efficiently transmit the data over the communication medium to a target receiver, where the original RF signal can be reconstructed.