The invention provides new methods for modulating specific CMI-inducing
cytokines in vivo. Such new methods result in stimulation of the
cytokines IL-6, IL-12 MIP-1.beta. and MCP without substantially inducing
undesired cytokines. The methods according to the invention are based
upon administration of oligonucleotides containing particular structural
motifs which lead to specific cytokine induction.