A thread scheduling mechanism is provided that flexibly enforces performance isolation of multiple threads to alleviate the effect of anti-cooperative execution behavior with respect to a shared resource, for example, hoarding a cache or pipeline, using the hardware capabilities of simultaneous multi-threaded (SMT) or multi-core processors. Given a plurality of threads running on at least two processors in at least one functional processor group, the occurrence of a rescheduling condition indicating anti-cooperative execution behavior is sensed, and, if present, at least one of the threads is rescheduled such that the first and second threads no longer execute in the same functional processor group at the same time.