A hollow fiber membrane cartridge comprising a bundle of multiple hollow fiber membranes arranged so as to be vertical in an immersion vessel and comprising bond fixing layers capable of bond fixing of the hollow fiber membrane bundle at both ends thereof, wherein the morphology of each of the bond fixing layers is selected from the group consisting of a triangle, a rectangle and a hexagon, and wherein at least an edge of upper side bond fixing layer, the hollow of the hollow fiber membranes opens, and wherein the hollow fiber membrane bundle at a filtration zone side interface of the upper side bond fixing layer is in the form of multiple wisps.