Microelectronic devices having an EMI shield, systems including such microelectronic devices, and methods for manufacturing such microelectronic devices. One embodiment of a microelectronic device comprises an imaging system comprising a microelectronic die, an optics assembly, and an electromagnetic interference (EMI) shield. The microelectronic die includes an image sensor, processing components electrically coupled to the image sensor, a first interconnect electrically isolated from the processing components, and a second interconnect electrically coupled to the processing components. The optics assembly is aligned with the image sensor, and the electromagnetic interference (EMI) shield is between the optics assembly and the processing components. The EMI shield is electrically coupled to the first interconnect.