New 3-substituted 4-(phenyl-N-alkyl)-piperazine and
4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N,
CH, or C, however X may only be C when the compound comprises a double
bind at the dotted line; R.sub.1 is CF.sub.3, OSO.sub.2CF.sub.3,
OSO.sub.2CH.sub.3, SOR.sub.7, SO.sub.2R.sub.7, COR.sub.7, CN, OR.sub.3,
NO.sub.2, CONHR.sub.3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F,
Cl, Br, or I; R.sub.2 is F, Cl, Br, I, CN, CF.sub.3, CH.sub.3, OCH.sub.3,
OH, and NH.sub.2; R.sub.3 and R.sub.4 are independently H or a
C.sub.1-C.sub.4 alkyl; R.sub.5 is a C.sub.1-C.sub.4 alkyl, an allyl,
CH.sub.2SCH.sub.3, CH.sub.2CH.sub.2OCH.sub.3, CH.sub.2CH.sub.2CH.sub.2F,
CH.sub.2CF.sub.3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or
--(CH.sub.2)R.sub.6; R.sub.6 is a C.sub.3-C.sub.6 cycloalkyl,
2-tetrahydrofurane, or 3-tetra-hydrofurane; R.sub.7 is a C.sub.1-C.sub.3
alkyl, CF.sub.3, or N(R.sub.4).sub.2, and pharmaceutically acceptable
salts thereof are disclosed. Also pharmaceutical compositions comprising
the above compounds and methods wherein the above compounds are used for
treatment of disorders in the central nervous system are disclosed.
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