The present invention relates to pyridazinone compounds and their
derivatives according to the general formula (I), with the substituents
X, R.sup.1 and R.sup.2 defined herein, as well as their physiologically
acceptable salts, methods for producing these compounds and their use as
pharmaceuticals. ##STR00001## These compounds are kinase inhibitors, in
particular inhibitors of the kinase GSK-3.beta. (glycogen synthase
kinase-3.beta.) which are useful in the treatment of neurodegenerative
diseases such as Alzheimer's disease, Parkinson's disease, strokes,
cranial and spinal traumas and peripheral neuropathies, obesity,
metabolic diseases, type II diabetes, essential hypertension,
atherosclerotic cardiovascular diseases, polycystic ovary syndrome and
syndrome X or immunodeficiency.