The invention relates to novel polynucleotides which encode novel
polypeptides that are acetylcholine-gated chloride channel subunits and
immunogenic or acetylcholine-binding fragments thereof. The novel
polypeptides may be used for identifying compounds that modulate the
acetylcholine-gated chloride channels, e.g. for use as pesticides and
antiparasitic agents. Methods for identifying compounds that modulate the
acetylcholine-gated chloride channels are provided.