Compounds having the structure (or their salts): ##STR00001## are used to
treat or reduce the likelihood of acquiring androgen-dependent diseases,
such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian
syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male
baldness. The compounds can be formulated together with pharmaceutically
acceptable diluents or carriers or otherwise made into any pharmaceutical
dosage form. Combinations with other active pharmaceutical agents are
also disclosed.