A computer system of a multi-operation-system (multi-OS) has a main memory having a memory area for a first OS and a memory area for a second OS, both the areas being independent from each other, and a plurality of I/O devices divisionally allocated to the first OS and the second OS. The first OS is loaded in the first OS memory area, and thereafter when the first OS is operated, the second OS is loaded in the second OS memory area and initialized. When the first OS is operated, the first OS hardware resources and the second OS hardware resources are registered by the first OS. Thereafter when the first OS is operated, the first OS inhibits the registration of an interrupt number already allocated to the second OS I/O device. In response to an interrupt request from a second OS I/O device, the second OS starts operating.