A system, method and apparatus for managing a patient affected with a disease. In one aspect, the invention is directed to an apparatus for managing a patient, the apparatus comprising a system that provides: A) a means for enrolling a patient into a system including storing general information about the patient into the system's database; B) a means for storing a schedule for the patient; C) a means for reminding the patient to execute the patient care activities; D) a means for retrieving patient information comprising responses to side effects questionnaires and laboratory results; E) a means for storing the patient information into the system; F) a means for analyzing the patient information and generating a recommendation; G) a means for submitting the recommendation to a provider for approval; and H) a means for receiving approval or a modified recommendation and sending the recommendation or modified recommendation to the patient.