Compounds of the formula (I) ##STR00001## provide pharmacological agents
which are inhibitors of the P450 enzyme, aldosterone synthase, and thus
may be employed for the treatment of aldosterone mediated conditions.
Accordingly, the compounds of formula (I) may be employed for prevention,
delay of progression, or treatment of hypokalemia, hypertension,
congestive heart failure, renal failure, in particular, chronic renal
failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy,
post-myocardial infarction, coronary heart diseases, increased formation
of collagen, fibrosis and remodeling following hypertension and
endothelial dysfunction. Preferred are the compounds of formula (I) which
are selective inhibitors of aldosterone synthase devoid of undesirable
side effects due to general inhibition of cytochrome P450 enzymes.