Disclosed are thrombin peptide derivatives comprising a polypeptide having
the amino acid sequence SEQ ID NO. 2:
Arg-Gly-Asp-Ala-Xaa-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal
truncated fragment of the polypeptide having at least six amino acids.
Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one,
two, or three amino acids in the polypeptide or polypeptide fragment
differ from the corresponding position of SEQ ID NO. 2. Also disclosed
are methods of treating a subject in need of treatment with a thrombin
receptor agonist. The methods comprise the step of administering an
effective amount of the thrombin peptide derivative described above.