The invention is a method of reducing catalyst dissolution in the cathode of a membrane electrode assembly fuel cell, the method comprising the steps of: (a) preparing a membrane electrode assembly comprising an anode, a cathode and a polymer electrolyte membrane interposed between the anode and the cathode; (b) assembling a fuel cell using the membrane electrode assembly; (c) applying a fluid comprising an oxidant to the cathode of the membrane electrode assembly; (d) applying a fluid comprising a fuel to the anode of the membrane electrode assembly; and (e) supplying a sufficient quantity of reducing agent to the cathode to maintain the average open-circuit voltage of the cathode at less than about 0.98 V.