A method for manufacturing a waterproof and vapor-permeable shoe, including preparing a semi-manufactured component of an upper for a shoe, to be arranged spread out on one or two flat surfaces, arranging on the inner part of the semi-manufactured component of an upper a waterproof and vapor-permeable membrane, then preparing an adhesive bonding between the semi-manufactured component of an upper and the membrane so as to not inhibit the vapor-permeability of the assembly. Flat shapes, suitable of shaping complementarily with respect to different thicknesses of stitched seams and of superimposed parts are prepared, and the membrane is coupled to the semi-manufactured component of an upper, with the outer part arranged resting on the shape. The upper is finished associated with an insole, and a sole.