The present invention relates to a compound represented by the formula:
(I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally
having substituent (s); U, V and W are each independently C or N,
provided that when any one of U, V and W is N, then the others should be
C; Ra and Rb are each independently a cyclic group optionally having
substituent(s), a C.sub.1-10alkyl group optionally having substituent(s),
a C.sub.2-10 alkenyl group optionally having substituent(s), or a
C.sub.2-10alkynyl group optionally having substituent(s); X is a bond, or
a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to
6 atoms in the main chain; Rc is a hydrocarbon group optionally
containing heteroatom(s) as the constituting atom(s), which optionally
has substituent(s); m and n are each independently 1 or 2; and ring B
optionally further has substituent(s), or a salt thereof. The compound of
the present invention has excellent renin inhibitory activity, and thus
is useful as an agent for the prophylaxis or treatment of hypertension,
various organ damages attributable to hypertension, and the like.
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