A prophylactic lubricant composition for use during sexual relations, includes: a) lubricant effective to reduce friction, thereby reducing the rupture of blood vessels during sexual relations, b) an effective amount of spermicidal antiseptic active against HIV and other viruses, said antiseptic destroying the human immunodeficiency virus and other viruses, said antiseptic immobilizing the sperm and reacting with vaginal mucosa to form a barrier to the penetration of sperm cells into the uterus; and c) an effective amount of a fungicide to prevent the growth of fungi in the vagina which grow in the absence of natural bacterial flora destroyed by the antiseptic; said composition having no substantial detrimental effect.