A method of repressing a cell-cycle gene, which is regulated by an E2F
transcription factor, in a cell, wherein the method comprises contacting
the cell with a cell-cycle gene-repressing amount of ErbB3 binding
protein (Ebp1); a method of inhibiting prostate cancer in a mammal,
wherein the method comprises administering to the mammal a prostate
cancer-inhibiting amount of Ebp1; a composition comprising an
Ebp1-expressing viral vector that expresses a cell-cycle gene-repressing
amount of Ebp1; and a composition comprising polymer-packaged DNA
comprising and expressing a cell-cycle gene-repressing amount of Ebp1.