An object of the present invention is to provide an antipruritic agent having a novel action mechanism.The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): ##STR00001## wherein R.sup.1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A.sup.1 and A.sup.2 represent a single bond or an alkylene group; E represents --NHCO--; A.sup.3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R.sup.3 represents a non-cyclic aliphatic hydrocarbon group; and R.sup.4 and R.sup.5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.