The present invention relates to compounds having estrogenic activity
selected from the group consisting of Loliolide,
(4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one,
(4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues
thereof. The compounds of the present invention are selective estrogen
receptor modulator, which can selectively activate ER.beta. and
simultaneously express high estrogenic activity, and also can be applied
as medical or food compositions to improve estrogen deficiency-related
symptoms.