A positive airway pressure therapy management module includes a user interface, a controller and memory. The module may include ports that capture data from a PAP device and/or from sensors. The user interface may display information and questions, and may receive answers. The controller may store data while offline from the network, and may respond to requests over the network while online with the network. A software product includes instructions that, under control of a computer, perform steps for managing positive airway pressure therapy of a patient. A method for managing positive airway pressure therapy of a patient captures data and communicates the data over a network. The method may capture data from a PAP device and/or from sensors, display questions and receiving answers, and calculate indices and/or metrics, perform a pressure titration, and/or relay commands to a PAP device in response to commands from the network.