A target interface system for flexibly routing and timing communication signals exchanged between selected components of a communication system and methods for manufacturing and using same. Under the control of a host system, the target interface system samples an output data signal provided by the host system and includes a reconfigurable datapath for flexibly routing the sampled data signal to a selected target I/O pin of the target interface system. The selected target I/O pin provides the sampled data signal as an outgoing target data signal to a target system and likewise receives an incoming target data signal from the target system. Upon sampling the incoming target data signal, the target interface system flexibly routes the sampled data signal to the host system as an input data signal. The target interface system thereby facilitates exchanges of communication signals between the host system and the target system.